[Mitochondria and oocyte maturation]. / Mitochondrie et maturation ovocytaire.
J Gynecol Obstet Biol Reprod (Paris)
; 39(1 Suppl): 11-3, 2010 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-20728799
ABSTRACT
Mitochondria play a central role in cellular energy metabolism. Mitochondrial genome (mtDNA) is specific with a maternal transmission. Defects of mtDNA, both quantitative (depletion) but also qualitative (mutation) were observed in patients with reproductive disorders, suggesting that a mitochondrial deficit could cause a failure of oocyte maturation. In our experience, some mtDNA point mutations would be subject to negative selection during female gametogenesis, with a threshold rate depending on the mutation. Below this threshold, the presence of mtDNA mutations would not impact oocyte maturation nor early embryonic development, as evidenced by the large number of oocytes and embryos carrying high mutation rates in our series.
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Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
DNA Mitocondrial
Idioma:
Fr
Ano de publicação:
2010
Tipo de documento:
Article