3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.

Denisenko, Aleksandr V; Mityuk, Andrey P; Grygorenko, Oleksandr O; Volochnyuk, Dmytro M; Shishkin, Oleg V; Tolmachev, Andrey A; Mykhailiuk, Pavel K

Denisenko, Aleksandr V; Mityuk, Andrey P; Grygorenko, Oleksandr O; Volochnyuk, Dmytro M; Shishkin, Oleg V; Tolmachev, Andrey A; Mykhailiuk, Pavel K.

Afiliação

Denisenko AV; Enamine Ltd., Vul. Oleksandra Matrosova 23, 01103 Kyiv, Ukraine.

Org Lett ; 12(19): 4372-5, 2010 Oct 01.

Article em En | MEDLINE | ID: mdl-20795656

ABSTRACT

ABSTRACT

An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.

Assuntos

Compostos de Benzil/síntese química; Compostos Bicíclicos com Pontes/síntese química; Heptanos/síntese química; Cristalografia por Raios X; Modelos Moleculares; Estrutura Molecular

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Benzil / Compostos Bicíclicos com Pontes / Heptanos Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google