Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
Int J Epidemiol
; 39(6): 1647-55, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20797988
ABSTRACT
BACKGROUND:
Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.METHODS:
To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.RESULTS:
The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.CONCLUSIONS:
Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Láctico
/
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article