Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease.
J Neuroimmunol
; 229(1-2): 157-68, 2010 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-20800908
ABSTRACT
Massive programmed cell death (PCD) of developing chick embryo motoneurons (MNs) occurs in a well defined temporal and spatial sequence between embryonic day (E) 6 and E10. We have found that, when administered in ovo, either circulating immunoglobulins G (IgGs) or cerebrospinal fluid from patients with MN disease can rescue a significant number of chick embryo MNs from normally occurring PCD. An increase of branching of intramuscular nerves was also observed that may account for the rescuing effects of pathologic IgGs. Proteomic analysis and further analysis by ELISA indicated that these effects may be mediated by the interaction of circulating human immunoglobulins with proteins of the semaphorin family.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Doença dos Neurônios Motores
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Apoptose
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Músculo Esquelético
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Neurônios Motores
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Junção Neuromuscular
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article