Genome scan for locus involved in mandibular prognathism in pedigrees from China.
PLoS One
; 5(9)2010 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-20844756
ABSTRACT
BACKGROUND:
It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped.METHODOLOGY:
In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Multipoint parametric and non-parametric (model-free) linkage analyses were used for the pedigrees. PRINCIPALFINDING:
The most statistically significant linkage results were with markers on chromosome 4 (LOD=3.166 and NPL=3.65 with rs 875864, 4p16.1, 8.38 cM). Candidate genes within the 4p16.1 include EVC, EVC2.CONCLUSION:
We detected a novel suggestive linkage locus for mandibular prognathism in two Chinese pedigrees, and this linkage region provides target for susceptibility gene identification, a process that will provide important insights into the molecular and cellular basis of mandibular prognathism.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Prognatismo
/
Estudo de Associação Genômica Ampla
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article