c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.
Head Neck
; 32(12): 1655-64, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20848408
ABSTRACT
BACKGROUND:
Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).METHODS:
Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.RESULTS:
The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.CONCLUSION:
The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Língua
/
Carcinoma de Células Escamosas
/
Proteínas Proto-Oncogênicas c-met
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article