Carboxylic acid-promoted copper(I)-catalyzed azide-alkyne cycloaddition.
J Org Chem
; 75(20): 7002-5, 2010 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-20849130
ABSTRACT
In this article, we proved that all three key steps in the catalytic cycle of CuAAC can proceed in the presence of carboxylic acids and the latter two steps can be promoted significantly by carboxylic acids. Benzoic acid showed the best promotion activity, and the acids with strong chelating ability to Cu(I) ion could not serve for this purpose. Thus, the first carboxylic acid-promoted highly efficient CuAAC was established.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Azidas
/
Triazóis
/
Ácidos Carboxílicos
/
Cobre
/
Alcinos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article