Understanding equivalence and noninferiority testing.
J Gen Intern Med
; 26(2): 192-6, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20857339
ABSTRACT
Increasingly, the goal of many studies is to determine if new therapies have equivalent or noninferior efficacies to the ones currently in use. These studies are called equivalence/noninferiority studies, and the statistical methods for their analysis require only simple modifications to the traditional hypotheses testing framework. Nevertheless, important and subtle issues arise with the application of such methods. This article describes the concepts and statistical methods involved in testing equivalence/noninferiority. The aim is to enable the clinician to understand and critically assess the growing number of articles utilizing such methods.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Equivalência Terapêutica
/
Compreensão
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article