Mechanisms of tubulointerstitial fibrosis.
J Am Soc Nephrol
; 21(11): 1819-34, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20864689
ABSTRACT
The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
/
Nefrite Intersticial
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article