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Simultaneous spectrofluorimetric determination of amlodipine besylate and valsartan in their combined tablets.
Shaalan, Rasha A; Belal, Tarek S.
Afiliação
  • Shaalan RA; Pharmaceutical Analytical Chemistry Department, University of Alexandria, Egypt.
Drug Test Anal ; 2(10): 489-93, 2010 Oct.
Article em En | MEDLINE | ID: mdl-20872895
ABSTRACT
Amlodipine, a dihydropyridine calcium channel blocker, and valsartan, an angiotensin II receptor blocker, are co-formulated in a single-dose combination for the treatment of hypertension. The combination is used by patients whose blood pressure is not adequately controlled on either component monotherapy. This work describes a simple, sensitive, and reliable spectrofluorimetric method for the simultaneous determination of the two antihypertensive drugs; amlodipine besylate (AML) and valsartan (VAL) in their combined tablets. The method involved measurement of the native fluorescence at 455 nm (λ(Ex) 360 nm) and 378 nm (λ(Ex) 245 nm) for AML and VAL, respectively. Analytical performance of the proposed spectrofluorimetric procedure was statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, robustness, detection, and quantification limits. Regression analysis showed good correlation between fluorescence intensity and concentration over the concentration ranges 0.2-3.6 and 0.008-0.080 µg mL⁻¹ for AML and VAL, respectively. The limits of detection were 0.025 and 0.0012 µg mL⁻¹ for AML and VAL, respectively. The proposed method was successfully applied for the assay of the two drugs in their combined pharmaceutical tablets with recoveries not less than 98.85%. No interference was observed from common pharmaceutical additives. The results were favourably compared with those obtained by a reference spectrophotometric method.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrofotometria / Comprimidos / Tetrazóis / Valina / Bloqueadores dos Canais de Cálcio / Anlodipino / Bloqueadores do Receptor Tipo 1 de Angiotensina II Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrofotometria / Comprimidos / Tetrazóis / Valina / Bloqueadores dos Canais de Cálcio / Anlodipino / Bloqueadores do Receptor Tipo 1 de Angiotensina II Idioma: En Ano de publicação: 2010 Tipo de documento: Article