Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers.
J Occup Environ Med
; 52(10): 1019-27, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20881620
ABSTRACT
OBJECTIVE:
This study evaluated health care worker exposure to antineoplastic drugs.METHODS:
A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay.RESULTS:
Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay.CONCLUSIONS:
Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
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Serviço Hospitalar de Oncologia
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Pessoal de Saúde
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article