Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.

ABSTRACT

Malignant mixed mesodermal tumors (MMMTs) are composed of carcinomatous and sarcomatous components and have an aggressive metastatic potential, resulting in a poor prognosis. MMMTs of gynecologic origin typically arise from either the ovary or the uterus, and MMMTs of the cervix are extremely rare. Due to the rarity of MMMTs arising from the cervix, there is no consensus regarding treatment, prognosis, and outcome; however, aggressive surgical cytoreduction, combined with adjuvant platinum-based chemotherapy and/or radiotherapy, is recommended as the treatment of choice for MMMTs of the cervix. Cervical MMMTs are more often confined to the uterus at the time of diagnosis and frequently have non-glandular epithelial components. For these reasons, MMMTs of the cervix may have a better prognosis compared to the uterine counterparts. A case of an immunohistochemically confirmed primary MMMT of the cervix, including components of a rhabdomyosarcoma, is reported.