Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.
Nat Neurosci
; 13(11): 1345-7, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20953195
ABSTRACT
In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling.
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Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Córtex Cerebral
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Regulação da Expressão Gênica no Desenvolvimento
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Corpo Estriado
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Proteínas de Ligação a DNA
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Células-Tronco Embrionárias
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Proteínas do Tecido Nervoso
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Neurônios
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article