Hepatitis C virus among non-injecting cocaine users (NICUs) in South America: can injectors be a bridge?
Addiction
; 106(1): 143-51, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20955486
ABSTRACT
AIM:
To investigate the factors associated with hepatitis C virus (HCV) infection among non-injecting cocaine users (NICUs) and to compare practices associated with HCV and HIV infection.DESIGN:
An intercountry cross-sectional study. Setting Buenos Aires and Montevideo metropolitan areas.PARTICIPANTS:
A total of 871 NICUs. MEASUREMENTS NICUs were interviewed and their blood was drawn and used for HCV, HIV, HBV surface antigen (HbsAg), HB-anticore and Venereal Disease Research Laboratory (VRDL) antibody assays. Bivariate and multivariate logistic regression analyses included comparisons of HCV and HIV mono-infected participants with HCV-HIV seronegatives.FINDINGS:
Prevalence rates were 8.8 [95% confidence interval (CI) 6.9-10.8) for HCV and 7.9 (95% CI 6.1-9.7) for HIV. HCV-infected NICUs were twice as likely as HCV-HIV seronegatives to have shared straws for cocaine snorting or sniffing, even when adjusted for other variables. HCV prevalence rates ranged from 3.6% among NICUs who denied sharing straws and having had an injection drug user (IDU) or an HIV-positive sexual partner to 12.6% among participants who reported ever having shared straws or having had either an IDU- or HIV-positive sexual partner (χ(2) (trend) = 6.56, P = 0.01).CONCLUSIONS:
Non-injecting cocaine users from South America are vulnerable to multiple infections and HCV infection appears to occur through the sharing of straws. HCV infection is associated with intimate relationships with IDUs or HIV-seropositive partners, supporting the hypothesis that HCV risk may be due primarily to risk-taking behaviour associated with drugs in this population.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Abuso de Substâncias por Via Intravenosa
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Hepatite C
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Cocaína
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Transtornos Relacionados ao Uso de Cocaína
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article