Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brain.
Neurosci Lett
; 487(2): 246-9, 2011 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-20970475
ABSTRACT
In this study we compared the biological activity of a unique form of gonadotropin-releasing hormone (GnRH) in the brain of the guinea pig (gpGnRH) with mammalian GnRH (mGnRH). In gpGnRH, the highly conserved histidine in position 2 (His(2)) and leucine in position 7 (Leu(7)) are substituted by tyrosine and valine, respectively. The gpGnRH was less potent than mGnRH in stimulating the release of luteinizing hormone (LH) in vivo in the guinea pig and displayed only low activity in the rat. The gpGnRH was more rapidly degraded by serum proteolytic enzymes than mGnRH. It is concluded that gpGnRH displays lower biological activity than mGnRH in both rat and guinea pig, which may be due in part to its greater susceptibility to proteolytic degradation besides differences in receptor affinity and/or activation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Hormônio Liberador de Gonadotropina
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article