[Use of monoclonal antibodies for studying cytochrome P-450 forms. Use of interspecies homology of amino acid sequence]. / Zastosowanie przeciwcial monoklonalnych do oznaczania odmian cytochromów P-450. Wykorzystanie miedzygatunkowych homologii sekwencji aminokwasów.

ABSTRACT

The current research on utilization of monoclonal antibodies for isolation of cytochrome P-450 forms, substrate specificity determination, localization in tissues and contribution in DNA adduct formation is reviewed in this paper. Usefulness of monoclonal antibodies directed against rodent cytochrome P-450 isoenzymes to human investigations is emphasized.