Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997-2007.
Clin Microbiol Infect
; 17(8): 1226-31, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21040157
ABSTRACT
Human infections caused by Weissella confusa are rarely reported. Ten patients with bacteraemia caused by W. confusa who were treated at a tertiary-care hospital in Taiwan during 1997-2007 were studied. All isolates were initially misidentified as various Lactobacillus and Leuconostoc species by two commercial automated identification methods, and were confirmed to be W. confusa by 16S rRNA sequencing analysis. MICs of these isolates for ten antimicrobial agents were determined by the agar dilution method. The characteristics of these patients included underlying malignancy (n = 4), presence of a central catheter (n = 6), surgery within the previous 3 months (n = 4) and concomitant polymicrobial bacteraemia (n = 5, 50%). Mortality was directly attributed to bacteraemia in two patients. All isolates exhibited high trimethoprim-sulphamethoxazole and ceftazidime MICs (≥ 128 mg/L) and were inhibited by linezolid, daptomycin, ceftobiprole and tigecycline at 4, 0.12, 2 and 0.12 mg/L, respectively. In conclusion, W. confusa should be included in the list of organisms causing bacteraemia in immunocompromised hosts. Novel antibiotics, including daptomycin, moxifloxacin, doripenem and tigecycline, exert good activity against W. confusa.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Positivas
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Bacteriemia
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Weissella
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Hospitais Universitários
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article