Total synthesis and antimalarial activity of symplostatin 4.
Org Lett
; 12(23): 5576-9, 2010 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-21049908
ABSTRACT
The first total synthesis of symplostatin 4, a marine cyanobacterium-derived natural product, is described. Notable features of the route include the efficient preparation of three key fragments and final assembly to the natural product via sequential imide and amide couplings. Symplostatin 4 was also demonstrated to possess significant antimalarial activity (ED(50) of 74 nM against Plasmodium falciparum, strain 3D7).
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Antimaláricos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article