Periodontal disease and pre-eclampsia: a systematic review.
J Clin Periodontol
; 37(12): 1075-87, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21070324
ABSTRACT
AIM:
This review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia. MAIN FINDINGS ANDCONCLUSION:
A literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Periodontais
/
Pré-Eclâmpsia
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article