Confirmation of neonatal screening: reference intervals and evaluation of methodological changes in TSH measurement.
J Pediatr Endocrinol Metab
; 23(8): 759-64, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-21073118
ABSTRACT
Neonatal reference values for serum thyrotropin are scarce and comprise only small numbers of patients. During 2006, changes were made in IMMULITE kits for TSH measurement. To validate methodological changes, 80 serum samples from patients were evaluated and to establish reference intervals, 334 neonates and infants were analyzed (divided into 4 groups). Group 1 (G1) (48-72 h of life) (n=153), group 2A (G2A) (7-10 days of life) (n=65), group 2B (G2B) (11-14 days of life) (n=35), group 3 (G3) (28-40 days of life) (n=81). Current kits overestimate TSH results by 26 to 37%; TSH (mIU/L) reference intervals (percentile 2.5-97.5) were G1 (1.1-12.7), G2A (1.8-9.8), G2B (1.1-7.1) (p < 0.03 vs. G2A), G3 (1.2-6.9). We suggest that during the second week of life, reference values should be divided into an early stage and a late stage, at least, for there to be an adequate interpretation of borderline measurements in newborn thyroid screening.
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Base de dados:
MEDLINE
Assunto principal:
Kit de Reagentes para Diagnóstico
/
Tireotropina
/
Triagem Neonatal
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article