The effects of postnatal estrogen therapy on brain development in preterm baboons.
Am J Obstet Gynecol
; 204(2): 177.e8-14, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21074139
ABSTRACT
OBJECTIVE:
Estrogen receptors are present within the fetal brain, suggesting that estrogens may exert an influence on cerebral development. Loss of placentally derived estrogen in preterm birth may impair development. STUDYDESIGN:
Baboons were delivered at 125 days of gestation (term approximately 185 days), randomly allocated to receive estradiol (n = 10) or placebo (n = 8), and ventilated for 14 days. Brains were assessed for developmental and neuropathological parameters.RESULTS:
Body and brain weights were not different between groups, but the brain/body weight ratio was increased (P < .05) in estradiol-treated animals. There were no differences (P > .05) between groups in any neuropathological measure in either the forebrain or cerebellum. There were no intraventricular hemorrhages; 1 estradiol animal displayed ectactic vessels in the subarachnoid space.CONCLUSION:
Brief postnatal estradiol administration to primates does not pose an increased risk of injury or impaired brain development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Nascimento Prematuro
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Estradiol
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article