The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells.
Cell Mol Life Sci
; 68(3): 341-52, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21080028
ABSTRACT
The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every pregnancy. It differs from classical HLA class I molecules by the low degree of allelic variants and the high diversity of protein structures. HLA-G is reported to be a tolerogenic molecule that acts on cells of both innate and adaptive immunity. At the maternal-fetal interface HLA-G seems to be responsible largely for the reprogramming of local maternal immune response. This review will focus on the HLA-G gene expression profile in pregnancy, in preimplantation embryos, and in human embryonic stem cells with emphasis on the structural diversity of the HLA-G protein and its potential functional and diagnostic implications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trofoblastos
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Blastocisto
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Gravidez
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Antígenos de Histocompatibilidade Classe I
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Perfilação da Expressão Gênica
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Células-Tronco Embrionárias
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Antígenos HLA
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article