Stereoselective synthesis of the C15-C26 fragment of the antitumor agent (-)-dictyostatin.
Org Biomol Chem
; 9(3): 758-64, 2011 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-21082125
ABSTRACT
The synthesis of the C15-C26 fragment of (-)-dictyostatin is reported in 10 steps and 28% overall yield. The key steps are the two stereoselective sulfoxide-directed processes a Reformatsky-type reaction and a ß-keto sulfoxide reduction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article