Two dimeric lignans with an unusual α,ß-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production.
Bioorg Med Chem Lett
; 21(1): 373-6, 2011 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-21087864
ABSTRACT
Two new dimeric lignans, zanthpodocarpins A (1) and B (2), and five known lignans, eudesmin (3), (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), dimethoxysamin (5), rel-(1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-2-one (6), and magnone A (7), were isolated from the barks of Zanthoxylum podocarpum. Their structures were identified by using spectroscopic methods. Compounds 1 and 2 are rare dilignans bearing an unusual α,ß-unsaturated ketone group from a natural source. Bioassay showed that compounds 1 and 2 could inhibit nitric oxide (NO) production in LPS stimulated RAW 264.7 cells with IC(50) values of 5.31 µM and 12.15 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lignanas
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Zanthoxylum
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Cetonas
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article