Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1).
Virol J
; 7: 330, 2010 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-21092081
ABSTRACT
BACKGROUND:
Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, ß- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37 °C in the presence of 5% CO2) using MDCK cell lines.RESULT:
Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples, followed by ß- lactoglobulin. α-Lactalbumin had less antiviral activity even after esterification.CONCLUSION:
Esterification of whey proteins fractions especially lactoferrin and ß-lactoglobulin enhanced their antiviral activity against H5N1 in a concentration dependent manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Virus da Influenza A Subtipo H5N1
/
Proteínas do Leite
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article