Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
Cancer Res
; 70(23): 9581-90, 2010 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-21098714
ABSTRACT
CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD
/
Linfócitos T Reguladores
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Proliferação de Células
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Melanoma
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article