The same synaptic vesicles drive active and spontaneous release.
Nat Neurosci
; 13(12): 1454-6, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21102450
ABSTRACT
Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin) in neuromuscular preparations from Drosophila, frog and mouse, as well as rat cultured neurons, we found that the same vesicles participate in active and spontaneous release.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Transmissão Sináptica
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Endocitose
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article