Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
Bioorg Med Chem Lett
; 20(24): 7283-7, 2010 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-21106451
ABSTRACT
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Inibidores de Proteases
/
Proteínas ADAM
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article