Ethyl 3-(4-fluoro-phen-yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxyl-ate.
Acta Crystallogr Sect E Struct Rep Online
; 64(Pt 1): o311-2, 2007 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-21200874
ABSTRACT
In the crystal structure of the title compound, C(22)H(24)FN(3)O(4), the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88â
(13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07â
(12)°. The cyclo-hexyl ring shows a distorted chair conformation. The mol-ecular structure is stabilized by intra-molecular C-Hâ¯O and C-Hâ¯N hydrogen-bonding inter-actions. The crystal packing is mainly stabilized by C-Hâ¯π hydrogen-bond inter-actions. Further stability is provided by C-Fâ¯π and C-Oâ¯π stacking inter-actions.
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MEDLINE
Idioma:
En
Ano de publicação:
2007
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Article