Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells.
PLoS One
; 5(12): e15694, 2010 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-21203530
ABSTRACT
Superantigens bind to major histocompatibility complex class II molecules and interact with T cells expressing a particular T cell receptor Vß inducing a strong proliferation/deletion response of the superantigen-reactive T cells. However, there have been no attempts to investigate the ability of Sags to induce apoptosis in neoplastic T cells by signaling through the Vß region of their TCR. In the present study we show that bacterial and MMTV-encoded superantigens induce the apoptosis of AKR/J cognate lymphoma T cells both in vitro and in vivo. The Fas-Fas-L pathway was shown to be involved in the apoptosis of lymphoma T cells induced by bacterial superantigens. In vivo exposure to bacterial superantigens was able to improve the survival of lymphoma bearing mice. Moreover, the permanent expression of a retroviral encoded superantigen induced the complete remission of an aggressive lymphoma in a high percentage of mice. The possibility of a therapeutic use of superantigens in lymphoma/leukemia T cell malignancies is discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfoma de Células T
/
Apoptose
/
Superantígenos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article