Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction.
Growth Horm IGF Res
; 21(1): 31-6, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21212012
ABSTRACT
OBJECTIVE:
The human Placental Growth Hormone (hPGH) and the Insulin-like Growth Factor (IGF) system are implicated in fetal development. This study aimed to evaluate the expression of hPGH, IGF-I, IGFBP-1 and IGFBP-3 genes in placentas from pregnancies complicated by fetal growth restriction (FGR).DESIGN:
The study group was comprised of term placentas from 47 FGR-complicated pregnancies of no recognizable cause. Thirty-seven placentas from normal pregnancies with appropriate for gestational age birth weight were used as controls. The expression status of the genes was evaluated by quantitative real-time PCR.RESULTS:
hPGH, IGF-I and IGFBP-1 exhibited significantly lower expression compared to the controls (p=0.003, p=0.049 and p=0.001, respectively). Numerically, lower IGFBP-3 expression was also demonstrated in the FGR-affected group, without however reaching statistical significance (p=0.129). Significant co-expression patterns were detected among the study genes in both the FGR and normal pregnancies.CONCLUSION:
Decreased placental expression levels of hPGH, IGF-I and IGFBP-1 were demonstrated in pregnancies with FGR. Whether these alterations are a causative factor of FGR or accompany other pathogenetic mechanisms requires further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
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Fator de Crescimento Insulin-Like I
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Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
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Hormônio do Crescimento Humano
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Retardo do Crescimento Fetal
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article