[Melanotic epithelioid clear cell tumor of kidney: report of three cases].
Zhonghua Bing Li Xue Za Zhi
; 39(12): 825-9, 2010 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-21215098
ABSTRACT
OBJECTIVE:
To study the pathologic features and immunophenotype of 3 cases of melanotic epithelioid clear cell tumor of kidney.METHODS:
More than 2000 cases of renal tumors were retrospectively reviewed. Three cases of melanotic epithelioid clear cell tumor were identified. Immunohistochemical study was carried out using the paraffin-embedded tissue samples. Electron microscopy was also performed in 1 case.RESULTS:
Amongst the 3 cases studied, the male-to-female ratio is 12. Histologically, 2 cases showed a clear cell carcinoma-like pattern. Papillary structures covered by clear cells and eosinophilic cells were observed in 1 case. Immunohistochemical study showed that the tumor cells in all cases expressed HMB 45. Two of them were also positive for Melan A. The staining for epithelial markers and S-100 protein was negative. Melanosomes were not identified by ultrastructural examination.CONCLUSIONS:
Melanotic epithelioid clear cell tumor is a rarely seen neoplasm of kidney. There are some histologic overlaps with renal cell carcinoma, epithelioid angiomyolipoma and melanoma. Immunohistochemical study is useful in confirming the diagnosis. The tumor represents a morphologic variant of epithelioid angiomyolipoma.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Células Epitelioides
/
Antígenos Específicos de Melanoma
/
Neoplasias Renais
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article