Expression of tropomyosin-&#954; induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.

Karam, Chehade N; Warren, Chad M; Rajan, Sudarsan; de Tombe, Pieter P; Wieczorek, David F; Solaro, R John

Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.

Karam, Chehade N; Warren, Chad M; Rajan, Sudarsan; de Tombe, Pieter P; Wieczorek, David F; Solaro, R John.

Afiliação

Karam CN; Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Ave. (M/C 901), Chicago, IL 60612-7342, USA.

J Muscle Res Cell Motil ; 31(5-6): 315-22, 2011 Mar.

Article em En | MEDLINE | ID: mdl-21221740

Assuntos

Citoesqueleto de Actina/metabolismo; Cardiomiopatia Dilatada/fisiopatologia; Contração Miocárdica; Tropomiosina/metabolismo; Animais; Cálcio/metabolismo; Cardiomiopatia Dilatada/genética; Camundongos; Camundongos Transgênicos; Fosforilação; Tropomiosina/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tropomiosina / Citoesqueleto de Actina / Cardiomiopatia Dilatada / Contração Miocárdica Idioma: En Ano de publicação: 2011 Tipo de documento: Article

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