Effect of selective monoamine oxidase A and B inhibitors on footshock induced aggression in paired rats.
Indian J Exp Biol
; 28(8): 742-5, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2123820
ABSTRACT
Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats. The doses and pretreatment times of the inhibitors used were based on an earlier reported in vivo dose-response and time-course study. In addition, apomorphine, a dopaminergic receptor agonist, and beta-phenylethylamine, a preferred substrate for MAO-B, were also used to garner corroborative evidence. The results of the study indicate that selective MAO-A inhibitors are likely to attenuate FIA by augmenting central serotonergic activity, while selective MAO-B inhibitors accentuate the behaviour by facilitating dopaminergic activity. A permissive role for noradrenaline could not be delineated by the available data.
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Base de dados:
MEDLINE
Assunto principal:
Selegilina
/
Clorgilina
/
Agressão
/
Nialamida
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article