Correlation of dynamic impact testing, histopathology and visual macroscopic assessment in human osteoarthritic cartilage.
Int Orthop
; 35(11): 1733-9, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21243357
ABSTRACT
OBJECTIVE:
Improved staging of cartilage degeneration is required, particularly during the early stages. We correlated mechanical properties with histological and macroscopic findings.METHODS:
One hundred and twenty cartilage samples were obtained during total knee arthroplasty. Two adjacent plugs were harvested--one for histological classification and one for macroscopic and biomechanical purposes. Dynamic impact testing was performed; normal stress, dissipated energy (∆E), tangent modulus and stiffness were evaluated.RESULTS:
Samples were classified according to six categories of the ICRS histological scale. Mechanical characteristics revealing significant differences between the groups (p < 0.01) were specific damping and related absolute ∆E. A significant correlation was found between the macroscopic score and specific damping, as well as absolute and relative ∆E (p < 0.01). A strong relation was revealed between relative ∆E and cartilage thickness (p < 0.001; R (2) = 0.69).CONCLUSIONS:
Only ∆E correlated with the condition of the cartilage--the value increased with decreasing quality-and is the most suitable characteristic. This change appears substantial in initial stages of cartilage deterioration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
/
Osteoartrite do Joelho
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article