Chemopreventive effects of dietary canola oil on colon cancer development.
Nutr Cancer
; 63(2): 242-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21264790
ABSTRACT
Fatty acid composition of dietary fat plays a vital role in colon tumor development in animal models. Fats containing ω-6 fatty acids (e.g., corn oil) enhanced and ω-3 fatty acids (e.g., flaxseed oil) reduced chemically induced colon tumor development in rats. The objective of the present investigation was to study the effects of dietary canola oil, a source of ω-3 fatty acid on azoxymethane-induced colon cancer development in Fischer rats and compare with dietary corn oil. Dietary canola oil significantly (P<0.05) decreased colonic tumor incidence and tumor multiplicity as compared to dietary corn oil in rats. Fatty acid analysis showed that corn oil group had higher levels of ω-6 fatty acid levels, whereas the canola oil groups exhibited higher levels of ω-3 fatty acids from the colon and serum samples of rats. For the mechanistic study, COX-2 expression in the colon samples from the canola oil group was significantly lower (P<0.05) as compared to the corn oil group. Taken together, dietary canola oil may be chemopreventive for colon tumor development in Fischer rats as compared to possibly by increasing ω-3 fatty acid levels and decreasing COX-2 levels.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azoximetano
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Ácidos Graxos Monoinsaturados
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Gorduras na Dieta
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Neoplasias do Colo
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Quimioprevenção
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Dieta
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article