Unusual approach to 3-aryl-2-aminopyridines through a radical mechanism: synthesis and theoretical rationale from quantum mechanical calculations.
J Org Chem
; 76(5): 1452-5, 2011 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-21265527
ABSTRACT
Tris(trimethylsilyl)silane and azobis(cyclohexanenitrile) promoted the easy intramolecular arylation of aryl bromopyridine carbamates through a radical [1,6] ipso substitution process. These substrates showed a preference for this type of reaction over the alternative [1,7] addition. The results were rationalized by making use of quantum mechanical calculations and computer graphics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Teoria Quântica
/
Aminopiridinas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article