The genetics of Tourette disorder.
Curr Opin Genet Dev
; 21(3): 302-9, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21277193
ABSTRACT
Tourette disorder (TD) is a childhood onset neuropsychiatric syndrome defined by persistent motor and vocal tics. Despite a long-standing consensus for a strong genetic contribution, the pace of discovery compared to other disorders of similar prevalence has been slow, due in part to a paucity of studies and both clinical heterogeneity and a complex genetic architecture. However, the potential for rapid progress is high. Recent rare variant findings have pointed to the importance of copy number variation, the overlap of risks among distinct diagnostic entities, the contribution of novel molecular mechanisms, and the value of family based studies. Finally, analysis of a cohort of sufficient size to identify common polymorphisms of plausible effect is underway, promising key information regarding the contribution of common alleles to TD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Tourette
/
Tiques
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article