Use of the predictive sugars biomarker to evaluate self-reported total sugars intake in the Observing Protein and Energy Nutrition (OPEN) study.
Cancer Epidemiol Biomarkers Prev
; 20(3): 490-500, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21278329
ABSTRACT
BACKGROUND:
A predictive biomarker for intake of total sugars was recently developed under controlled conditions. We used this biomarker to assess measurement error (ME) structure in self-reported intake of total sugars in free-living individuals.METHODS:
The Observing Protein and Energy Nutrition (OPEN) study involved 484 participants aged 40 to 69 years. Diet was assessed using two administrations of a food frequency questionnaire (FFQ) and two nonconsecutive 24-hour dietary recalls (24HDR). Two 24-hour urine samples checked for completeness were analyzed on sucrose and fructose. We applied the biomarker calibrated in a feeding study to OPEN data to assess the ME structure and the attenuation factors (AF) for intakes of absolute total sugars and sugars density for the FFQ and 24HDR.RESULTS:
The AFs for absolute sugars were similar for a single FFQ and 24HDR, but attenuation decreased with repeated 24HDRs. For sugars density, the AFs for FFQ (men 0.39; women 0.33) were greater than for single 24HDR (men 0.30; women 0.24), and similar to two 24HDRs (men 0.41; women 0.35). The attenuation associated with both instruments was greater in women than in men.CONCLUSIONS:
Both the FFQ and 24HDR were found to be biased; hence, incorporation of the sugars biomarker in calibration studies within the cohorts may be necessary to more reliably estimate associations of sugars and disease. IMPACT In this article, we propose a new dietary reference instrument based on the recently defined class of predictive biomarkers. Using sugars biomarker, we quantify ME in the FFQ- and 24HDR-reported absolute total sugars and total sugars density.
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Base de dados:
MEDLINE
Assunto principal:
Registros de Dieta
/
Sacarose Alimentar
/
Autorrelato
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article