Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619.
J Antibiot (Tokyo)
; 64(3): 257-66, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21285962
ABSTRACT
Phenelfamycins G and H are new members of the family of elfamycin antibiotics with the basic structure of phenelfamycins E and F, respectively, which are also well known as ganefromycins α and ß. Phenelfamycins G and H differ from phenelfamycins E and F by an additional hydroxy group at position C-30, which is not described so far for any of the elfamycin-type antibiotics. The actinomycete strain that produced phenelfamycins G and H was identified to be Streptomyces albospinus based on its 16S rRNA gene sequence. Phenelfamycins G and H exhibit a narrow antibacterial spectrum with a pronounced inhibitory activity against Propionibacterium acnes.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Aminoglicosídeos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article