Photo-DHEA--a functional photoreactive dehydroepiandrosterone (DHEA) analog.
Steroids
; 76(5): 502-7, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21291900
ABSTRACT
The steroid hormone dehydroepiandrosterone (DHEA) has beneficial effects on vascular function, survival of neurons, and fatty acid metabolism. However, a specific receptor for DHEA has not been identified to date. Here, we describe the synthesis of a photoreactive DHEA derivative (Photo-DHEA). In Photo-DHEA, typical characteristics of DHEA are conserved (i) a "planar" tetracyclic ring system with a Δ(5) double bond, (ii) a 3ß-hydroxyl group, and (iii) a keto group at C17. In cell-based assays, Photo-DHEA showed the same properties as DHEA. We conclude that Photo-DHEA is suitable for radioiodination to yield a tool for the identification of the elusive DHEA receptor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
/
Receptores de Esteroides
/
Desidroepiandrosterona
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article