Reshaping of bulbar odor response by nasal flow rate in the rat.
PLoS One
; 6(1): e16445, 2011 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-21298064
ABSTRACT
BACKGROUND:
The impact of respiratory dynamics on odor response has been poorly studied at the olfactory bulb level. However, it has been shown that sniffing in the behaving rodent is highly dynamic and varies both in frequency and flow rate. Bulbar odor response could vary with these sniffing parameter variations. Consequently, it is necessary to understand how nasal airflow can modify and shape odor response at the olfactory bulb level. METHODOLOGY AND PRINCIPALFINDINGS:
To assess this question, we used a double cannulation and simulated nasal airflow protocol on anesthetized rats to uncouple nasal airflow from animal respiration. Both mitral/tufted cell extracellular unit activity and local field potentials (LFPs) were recorded. We found that airflow changes in the normal range were sufficient to substantially reorganize the response of the olfactory bulb. In particular, cellular odor-evoked activities, LFP oscillations and spike phase-locking to LFPs were strongly modified by nasal flow rate.CONCLUSION:
Our results indicate the importance of reconsidering the notion of odor coding as odor response at the bulbar level is ceaselessly modified by respiratory dynamics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Olfato
/
Inalação
/
Odorantes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article