Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses.
J Virol
; 85(9): 4618-22, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21325417
ABSTRACT
Acyclovir, a nucleoside analog, is thought to be specific for the human herpesviruses because it requires a virally encoded enzyme to phosphorylate it to acyclovir monophosphate. Recently, acyclovir triphosphate was shown to be a direct inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Here, we showed that acyclovir is an inhibitor of HIV-1 replication in CD4(+) T cells from cord blood that have undetectable levels of the eight human herpesviruses. Additionally, acyclovir phosphates were detected by reverse-phase-high performance liquid chromatography (RP-HPLC) and quantified in a primer extension assay from cord blood. The data support acyclovir as an inhibitor of HIV-1 replication in herpesvirus-negative cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Aciclovir
/
Linfócitos T CD4-Positivos
/
HIV-1
/
Herpesviridae
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article