Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.
Alzheimers Res Ther
; 3(1): 5, 2011 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-21329517
ABSTRACT
INTRODUCTION:
Levels of cerebrospinal fluid (CSF) ß-amyloid (Aß) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear.METHODS:
We assessed cognitive function and assayed CSF Aß and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations.RESULTS:
CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aß1-40's relationship was biphasic.CONCLUSIONS:
Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all.
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MEDLINE
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article