Navigating the kinome.
Nat Chem Biol
; 7(4): 200-2, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21336281
ABSTRACT
Although it is increasingly being recognized that drug-target interaction networks can be powerful tools for the interrogation of systems biology and the rational design of multitargeted drugs, there is no generalized, statistically validated approach to harmonizing sequence-dependent and pharmacology-dependent networks. Here we demonstrate the creation of a comprehensive kinome interaction network based not only on sequence comparisons but also on multiple pharmacology parameters derived from activity profiling data. The framework described for statistical interpretation of these network connections also enables rigorous investigation of chemotype-specific interaction networks, which is critical for multitargeted drug design.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Proteínas Quinases
/
Proteoma
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article