MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine.
Biotechnol Lett
; 33(7): 1473-80, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21344205
ABSTRACT
Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).
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Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Fosfosserina
/
Crânio
/
Células-Tronco
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Diferenciação Celular
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article