Pharmacoeconomics of darunavir.
Expert Rev Pharmacoecon Outcomes Res
; 11(1): 27-39, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21351854
ABSTRACT
Darunavir boosted with ritonavir (DRV/r) in combination with other antiretrovirals (ARVs) was initially approved in 2006 for the treatment of HIV infection in ARV treatment-experienced adults and has subsequently been approved for use in treatment-naive adults in 2008. Clinical studies have shown that DRV/r in combination with other ARVs achieves superior levels of undetectable plasma HIV RNA and generates significant CD4 increases, which reduce the risk of HIV disease progression. Economic evaluations, based on data from controlled clinical trials, found DRV/r combination therapy to generate savings in hospital costs and other non-ARV costs of care in treatment-experienced patients, to maximize the number of patients reaching undetectable plasma HIV RNA, to improve health-related quality of life and quality-adjusted life expectancy, and to be cost effective across different patient populations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Infecções por HIV
/
Inibidores da Protease de HIV
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article