Targets for preventing epilepsy following cortical injury.
Neurosci Lett
; 497(3): 172-6, 2011 Jun 27.
Article
em En
| MEDLINE
| ID: mdl-21354270
ABSTRACT
Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Lesões Encefálicas
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Modelos Animais de Doenças
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Epilepsia
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Anticonvulsivantes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article