Bcl-2-regulated cell death signalling in the prevention of autoimmunity.
Cell Death Dis
; 1: e48, 2010 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-21364654
ABSTRACT
Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Transdução de Sinais
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Proteínas Proto-Oncogênicas c-bcl-2
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article