The diagnostic value of the anti-PF4/heparin immunoassay high-dose heparin confirmatory test in cardiac surgery patients.
Anesth Analg
; 112(4): 774-6, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21385980
ABSTRACT
There are limited and conflicting data on how a confirmatory step using high-dose heparin can improve diagnostic specificity of the antiplatelet factor 4/heparin enzyme immunoassay for heparin-induced thrombocytopenia (HIT). We investigated sera from a recently published study on cardiac surgery patients and found that only half of the sera that were heparin-induced platelet activation assay positive could be inhibited (optical density <40%) by high-dose heparin (100 IU/mL) in the enzyme immunoassay. More importantly, only 2 of the 3 patients with definite HIT were confirmatory test positive. Therefore, the high-dose heparin confirmatory test should be used with caution to exclude platelet-activating antiplatelet factor 4/heparin antibodies or clinical HIT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator Plaquetário 4
/
Heparina
/
Procedimentos Cirúrgicos Cardíacos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article